Publications

Recent Publications

Global stabilization of the transcriptome in mitotic cells
Ekaterina Khalizeva, Arash Latifkar, Kehui Xiang, David P Bartel, Jimmy Ly, Iain M. Cheeseman
The EMBO Journal
Regulation of mRNA decay and translation during the mammalian cell cycle
Jimmy Ly, Ekaterina Khalizeva, Yi Fei Tao, Iain M. Cheeseman
RNA
P614: The importance of alternative transcript analysis in rare disease diagnosis: A case series
Casie Genetti, Katherine Anderson, Tabitha Poorvu, Elicia Estrella, Regina Laine, Catherine Brownstein, Jimmy Ly, Iain M. Cheeseman, A. Beggs, Vijay Ganesh, Monica H. Wojcik
Genetics in Medicine Open
5′ UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease
Jimmy Ly, Eric M Smith, Matteo Di Bernardo, Yi Fei Tao, Elizabeth M. Black, Ekaterina Khalizeva, Iain M. Cheeseman
EMBO Reports
Adaptive evolution of CENP-T modulates centromere binding
Damian Dudka, Alexandra L. Nguyen, Katelyn G. Boese, Océane Marescal, R. Brian Akins, Ben E. Black, Iain M. Cheeseman, Michael A. Lampson
Current Biology
Alternative start codon selection shapes mitochondrial function and rare human diseases
Jimmy Ly, Matteo Di Bernardo, Yi Fei Tao, Ekaterina Khalizeva, Christopher J. Giuliano, Sebastian Lourido, Mark D. Fleming, Iain M. Cheeseman
Molecular Cell
RNase MRP subunit composition and role in 40S ribosome biogenesis
Eric M. Smith, Jimmy Ly, S. Haug, Iain M. Cheeseman
Nature Structural & Molecular Biology
19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
Océane Marescal, Iain M. Cheeseman
Cell Reports
Molecular determinants of RNase MRP specificity and function
Eric M. Smith, Jimmy Ly, S. Haug, Iain M. Cheeseman
bioRxiv
Brieflow: An Integrated Computational Pipeline for High-Throughput Analysis of Optical Pooled Screening Data
Matteo Di Bernardo, Roshan S. Kern, Ana Karla Cepeda Diaz, Alexa Mallar, Samuel J. Choi, Andrew Nutter-Upham, Sebastian Lourido, Paul C. Blainey, Iain M. Cheeseman
bioRxiv
The dynamics of centromere assembly and disassembly during quiescence
Océane Marescal, Kuan-Chung Su, Brittania Moodie, Naomi Taylor, Iain M. Cheeseman
The Journal of Cell Biology
KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
Jiahang Miao, Masatoshi Hara, Kuan-Chung Su, Heather R. Keys, Weixia Kong, Yusuke Takenoshita, Iain M. Cheeseman, Tatsuo Fukagawa
Cell Reports
Differential roles for the spindle assembly checkpoint in error surveillance and mitotic timing
Ryan K. Kim, Kuan-Chung Su, Mary-Jane Tsang, Nolan K. Maier, Brittania Moodie, Iain M. Cheeseman
bioRxiv
SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program
Jimmy Ly, Sarah L. Cady, Ekaterina Khalizeva, S. Haug, Iain M. Cheeseman
bioRxiv
Functional genetics with a hypomorphic CENP-C mutant reveals a regulatory system for chromosome congression
Jiahang Miao, Masatoshi Hara, Kuan-Chung Su, Heather R. Keys, Weixia Kong, Yusuke Takenoshita, Iain M. Cheeseman, Tatsuo Fukagawa
bioRxiv
Nuclear release of eIF1 restricts start-codon selection during mitosis
Jimmy Ly, Kehui Xiang, Kuan-Chung Su, Gunter B. Sissoko, David P. Bartel, Iain M. Cheeseman
Nature
Higher-order protein assembly controls kinetochore formation
Gunter B. Sissoko, Ekaterina V. Tarasovetc, Océane Marescal, Ekaterina L. Grishchuk, Iain M. Cheeseman
Nature Cell Biology
A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development
Jimmy Ly, Cecilia S. Blengini, Sarah L. Cady, Karen Schindler, Iain M. Cheeseman
Current Biology
Co-essentiality analysis identifies PRR12 as a cohesin interacting protein and contributor to genomic integrity
Alexandra L. Nguyen, Eric M. Smith, Iain M. Cheeseman
Developmental Cell
Functional genetics reveals modulators of antimicrotubule drug sensitivity
Kuan-Chung Su, Elena Radul, Nolan K. Maier, Mary‐Jane Tsang, Claire S. Goul, Brittania Moodie, Océane Marescal, Heather R. Keys, Iain M. Cheeseman
The Journal of Cell Biology
Cell biology is…
Julie A. Theriot, Anne Simonsen, Iva M. Tolić, Manuel D. Leonetti, Satyajit Mayor, Patricia Bassereau, Ewa K. Paluch, Jiahuai Han, Markus W. Covert, Noboru Mizushima, Samara L. Reck‐Peterson, Andreas Strasser, Iain M. Cheeseman
Cell
Binding site maturation modulated by molecular density underlies Ndc80 binding to kinetochore receptor CENP-T
Ekaterina V. Tarasovetc, Gunter B. Sissoko, Aleksandr Maiorov, Anna S. Mukhina, Fazoil I. Ataullakhanov, Iain M. Cheeseman, Ekaterina L. Grishchuk
Proceedings of the National Academy of Sciences
Structural constraints and drivers of molecular evolution in a macromolecular complex; the kinetochore
Hannah K. Pare, Alexandra L. Nguyen, M. Sabrina Pankey, Iain M. Cheeseman, David C. Plachetzki
bioRxiv
Alternative CDC20 translational isoforms tune mitotic arrest duration
Mary‐Jane Tsang, Iain M. Cheeseman
Nature
The phenotypic landscape of essential human genes
Luke Funk, Kuan-Chung Su, Jimmy Ly, David Feldman, Avtar Singh, Brittania Moodie, Paul C. Blainey, Iain M. Cheeseman
Cell
Identification of a Golgi-localized peptide reveals a minimal Golgi-targeting motif
Alexandra P. Navarro, Iain M. Cheeseman
Molecular Biology of the Cell
Dynamic cell cycle–dependent phosphorylation modulates CENP-L–CENP-N centromere recruitment
Alexandra P. Navarro, Iain M. Cheeseman
Molecular Biology of the Cell
Kinetochore assembly throughout the cell cycle
Alexandra P. Navarro, Iain M. Cheeseman
Seminars in Cell and Developmental Biology
Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition
Nolan K. Maier, Jun Ma, Michael A. Lampson, Iain M. Cheeseman
Developmental Cell
Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways
Alexandra Nguyen, Marie Diane Fadel, Iain M. Cheeseman
Molecular Biology of the Cell
Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes
S. Zachary Swartz, Hieu Nguyen, Brennan C McEwan, Mark E. Adamo, Iain M. Cheeseman, Arminja N. Kettenbach
eLife
Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes
S. Zachary Swartz, Tzer Han Tan, Margherita Perillo, Nikta Fakhri, Gary M. Wessel, Athula H. Wikramanayake, Iain M. Cheeseman
Current Biology
Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts
Ekaterina V. Tarasovetc, Praveen Kumar Allu, Robert T. Wimbish, Jennifer G. DeLuca, Iain M. Cheeseman, Ben E. Black, Ekaterina L. Grishchuk
Molecular Biology of the Cell
Cellular Mechanisms and Regulation of Quiescence
Océane Marescal, Iain M. Cheeseman
Developmental Cell
Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations
Leah Bury, Brittania Moodie, Jimmy Ly, Liliana S. McKay, Karen H. Miga, Iain M. Cheeseman
eLife
Cohesin Removal Reprograms Gene Expression upon Mitotic Entry
Carlos Perea-Resa, Leah Bury, Iain M. Cheeseman, Michael D. Blower
Molecular Cell
Chromosome Segregation: Evolving a Plastic Chromosome-Microtubule Interface
Navarro AP, Cheeseman IM
Current biology : CB
Reconstitution of human kinetochore in mitotic cell extracts reveals permitted and restricted assembly steps
Ekaterina V. Tarasovetc, Praveen Kumar Allu, Iain M. Cheeseman, Ben E. Black, Ekaterina L. Grishchuk
bioRxiv
Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential
S. Zachary Swartz, Liliana S. McKay, Kuan-Chung Su, Leah Bury, Abbas Padeganeh, Paul S. Maddox, Kristin A. Knouse, Iain M. Cheeseman
Developmental Cell
The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn
F. Esra Demircioglu, Weili Zheng, Alexander J. McQuown, Nolan K. Maier, Nicki Watson, Iain M. Cheeseman, Vladimir Denic, Edward H. Egelman, Thomas Schwartz
Nature Communications
Noninvasive imaging of 3D dynamics in the cell nucleus
Yoon Hee Jung, Kuan-Chung Su, Blox Bloxham, Iain M. Cheeseman, Nikta Fakhri
APS
Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion
José-Antonio Rodriguez-Rodriguez, Clare M. Lewis, Kara L. McKinley, Vitali Sikirzhytski, Jennifer Corona, John Maciejowski, Alexey Khodjakov, Iain M. Cheeseman, Prasad V. Jallepalli
Current Biology
The kinetochore–microtubule interface at a glance
Julie K. Monda, Iain M. Cheeseman
Journal of Cell Science
Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype
Attya Omer, Yun Li, Julien Muffat, Kuan-Chung Su, Malkiel A. Cohen, Tenzin Lungjangwa, Patrick Aubourg, Iain M. Cheeseman, Rudolf Jaenisch
Cell Reports
Ectopic Activation of the Spindle Assembly Checkpoint Signaling Cascade Reveals Its Biochemical Design
Chu Chen, Ian P. Whitney, Anand Banerjee, Carlos Sacristán, Palak Sekhri, David M. Kern, Adrienne Fontan, Geert J.P.L. Kops, John J. Tyson, Iain M. Cheeseman, Ajit P. Joglekar
Current Biology
Nde1 promotes diverse dynein functions through differential interactions and exhibits an isoform-specific proteasome association
Julie K. Monda, Iain M. Cheeseman
Molecular Biology of the Cell
CRISPR/Cas9-based gene targeting using synthetic guide RNAs enables robust cell biological analyses
Kuan-Chung Su, Mary‐Jane Tsang, Neil Emans, Iain M. Cheeseman
Molecular Biology of the Cell
Dynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes
Julie K. Monda, Iain M. Cheeseman
Open Biology
The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochores
José-Antonio Rodriguez-Rodriguez, Kara L. McKinley, Vitali Sikirzhytski, Jennifer Corona, John Maciejowski, Alexey Khodjakov, Iain M. Cheeseman, Prasad V. Jallepalli
bioRxiv
Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects
Kara L. McKinley, Iain M. Cheeseman
Developmental Cell
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition
Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulić, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman, Ben E. Black
Nature Communications
Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80
David M. Kern, Julie K. Monda, Kuan-Chung Su, Elizabeth M. Wilson-Kubalek, Iain M. Cheeseman
eLife
Microtubule Tip Tracking by the Spindle and Kinetochore Protein Ska1 Requires Diverse Tubulin-Interacting Surfaces
Julie K. Monda, Ian P. Whitney, Ekaterina V. Tarasovetc, Elizabeth M. Wilson-Kubalek, Ronald A. Milligan, Ekaterina L. Grishchuk, Iain M. Cheeseman
Current Biology
Probing 4D chromatin dynamics in live cells
Yoon Hee Jung, Kuan-Chung Su, Iain M. Cheeseman, Nikta Fakhri
Bulletin of the American Physical Society
A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
Kuan-Chung Su, Zachary Barry, Nina Schweizer, Hélder Maiato, Mark Bathe, Iain M. Cheeseman
Cell Reports
A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends
David M. Kern, Peter K. Nicholls, David C. Page, Iain M. Cheeseman
The Journal of Cell Biology
Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior
Elizabeth M. Wilson-Kubalek, Iain M. Cheeseman, Ronald A. Milligan
Molecular Biology of the Cell
Structural analysis of CENP-H complex by CryoEM
Fumiaki Makino, Kara L. McKinley, Masatoshi Hara, Tetsuya Hori, Takayuki Kato, Iain M. Cheeseman, Keiichi Namba, Tatsuo Fukagawa
The molecular basis for centromere identity and function
Kara L. McKinley, Iain M. Cheeseman
Nature Reviews Molecular Cell Biology
The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface
Kara L. McKinley, Nikolina Sekulić, Lucie Y. Guo, Tonia Tsinman, Ben E. Black, Iain M. Cheeseman
Molecular Cell
Inferring transient particle transport dynamics in live cells
Nilah Monnier, Zachary Barry, Hye Yoon Park, Kuan-Chung Su, Zachary Katz, Brian P. English, Arkajit Dey, Keyao Pan, Iain M. Cheeseman, Robert H. Singer, Mark Bathe
Nature Methods
Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T
Florencia Rago, Karen E. Gascoigne, Iain M. Cheeseman
Current Biology
Bayesian Classification of Mrna and Kinetochore Transport Dynamics
Zachary Barry, Nilah Monnier, Hye Yoon Park, Kuan-Chung Su, Zachary Katz, Brian P. English, Arkajit Dey, Keyao Pan, Iain M. Cheeseman, Robert H. Singer, Mark Bathe
Biophysical Journal
Chromosome Segregation: A Spatial Code to Correct Kinetochore-Microtubule Attachments
Monda JK, Cheeseman IM
Current biology : CB
The Kinetochore
Iain M. Cheeseman
Cold Spring Harbor Perspectives in Biology
Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres
Kara L. McKinley, Iain M. Cheeseman
Cell
Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program
Prathapan Thiru, David M. Kern, Kara L. McKinley, Julie K. Monda, Florencia Rago, Kuan-Chung Su, Tonia Tsinman, Defne Yarar, George W. Bell, Iain M. Cheeseman
Molecular Biology of the Cell
The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes
David M. Kern, Tae-Kyung Kim, Mike Rigney, Neil Hattersley, Arshad Desai, Iain M. Cheeseman
Molecular Biology of the Cell
Cortical Dynein and Asymmetric Membrane Elongation Coordinately Position the Spindle in Anaphase
Tomomi Kiyomitsu, Iain M. Cheeseman
Cell
CENP‐T provides a structural platform for outer kinetochore assembly
Tatsuya Nishino, Florencia Rago, Tetsuya Hori, Kentaro Tomii, Iain M. Cheeseman, Tatsuo Fukagawa
The EMBO Journal
CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state
Karen E. Gascoigne, Iain M. Cheeseman
The Journal of Cell Biology
Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis
Nina Schweizer, Cristina Ferrás, David M. Kern, Elsa Logarinho, Iain M. Cheeseman, Hélder Maiato
The Journal of Cell Biology
Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis
Karen E. Gascoigne, Iain M. Cheeseman
Chromosome Research
The functions and consequences of force at kinetochores
Florencia Rago, Iain M. Cheeseman
The Journal of Cell Biology
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
William C. Earnshaw, Robin C. Allshire, Ben E. Black, Kerry Bloom, B. R. Brinkley, William R. Brown, Iain M. Cheeseman, K. H. Andy Choo, Gregory P. Copenhaver, Jennifer G. DeLuca, Arshad Desai, Stephan Diekmann, Sylvia Erhardt, Molly Fitzgerald‐Hayes, Daniel R. Foltz, Tatsuo Fukagawa, Reto Gassmann, Daniel W. Gerlich, David M. Glover, Gary J. Gorbsky, Stephen C. Harrison, Patrick Heun, Toru Hirota, Lars E.T. Jansen, Gary H. Karpen, Geert J.P.L. Kops, Michael A. Lampson, Susanne M.A. Lens, Ana Losada, Karolin Luger, Hélder Maiato, Paul S. Maddox, Robert L. Margolis, Hiroshi Masumoto, Andrew D. McAinsh, Barbara G. Mellone, Patrick Meraldi, A. Musacchio, Karen Oegema, Rachel J. O’Neill, Edward D. Salmon, Kristin C. Scott, Aaron F. Straight, P. Todd Stukenberg, Beth A. Sullivan, Kevin F. Sullivan, Cláudio E. Sunkel, Jason R. Swedlow, Claire Walczak, Peter E. Warburton, Stefan Westermann, H F Willard, Linda Wordeman, Mitsuhiro Yanagida, Tim J. Yen, K. Yoda, Don W. Cleveland
Chromosome Research
Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1
Andras Boeszoermenyi, Jens C. Schmidt, Iain M. Cheeseman, Monika Oberer, Gerhard Wagner, Haribabu Arthanari
Biomolecular NMR Assignments
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
Tomomi Kiyomitsu, Iain M. Cheeseman
Nature Cell Biology
CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Tatsuya Nishino, K. Takeuchi, Karen E. Gascoigne, Aussie Suzuki, Tetsuya Hori, Takuji Oyama, Kosuke Morikawa, Iain M. Cheeseman, Tatsuo Fukagawa
Cell
The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments
Jens C. Schmidt, Haribabu Arthanari, Andras Boeszoermenyi, Natalia M. Dashkevich, Elizabeth M. Wilson-Kubalek, Nilah Monnier, Michelle A. Markus, Monika Oberer, Ron Milligan, Mark Bathe, Gerhard Wagner, Ekaterina L. Grishchuk, Iain M. Cheeseman
Developmental Cell
Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
Ana Maia, Zaira García, Lilian Kabeche, Marin Barišić, Stefano Maffini, Sandra Macedo‐Ribeiro, Iain M. Cheeseman, Duane A. Compton, Irina Kaverina, Hélder Maiato
The Journal of Cell Biology
The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle
Julie P. I. Welburn, Iain M. Cheeseman
Molecular Biology of the Cell
LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote Sister Chromatid Cohesion
Yonatan B. Tzur, Carlos Egydio de Carvalho, Saravanapriah Nadarajan, Ivo van Bostelen, Yanjie Gu, Diana S. Chu, Iain M. Cheeseman, Mónica P. Colaiácovo
PLoS Biology
CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development
Chelsea B. Backer, Jennifer H. Gutzman, Chad G. Pearson, Iain M. Cheeseman
Molecular Biology of the Cell
Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1.
Alexander Lorestani, F. Douglas Ivey, Sivasakthivel Thirugnanam, Michele Busby, Gábor Marth, Iain M. Cheeseman, Marc‐Jan Gubbels
PubMed
Kinetochore Structure: Pulling Answers from Yeast
Iain M. Cheeseman, David M. Kern
Building a path in cell biology
Gia K. Voeltz, Iain M. Cheeseman
Molecular Biology of the Cell
T time for point centromeres
Gascoigne KE, Cheeseman IM
Nature cell biology
Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes
Karen E. Gascoigne, K. Takeuchi, Aussie Suzuki, Tetsuya Hori, Tatsuo Fukagawa, Iain M. Cheeseman
Cell
Affinity Purification of Protein Complexes in C. elegans
Esther Zanin, Julien Dumont, Reto Gassmann, Iain M. Cheeseman, Paul S. Maddox, Shirin Bahmanyar, Ana Xavier Carvalho, Sherry Niessen, John R. Yates, Karen Oegema, Arshad Desai
Methods in cell biology
Chromosome Segregation: Keeping Kinetochores in the Loop
Jens C. Schmidt, Iain M. Cheeseman
Current Biology
Molecular-Mechanical Model of Kinetochore-Microtubule Interactions Identifies Flexibility of the Kinetochore Mesh as a Key Determinant of Errorless Bi-Orientation
Fazly I. Ataullakhanov, Anatoly V. Zaytsev, Julie P. I. Welburn, Iain M. Cheeseman, Ekaterina L. Grishchuk
Biophysical Journal
Anatomy of a kinetochore: Building a microtubule attachment site
Iain M. Cheeseman
The FASEB Journal
Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface
Julie P. I. Welburn, Mathijs Vleugel, Dan Liu, John R. Yates, Michael A. Lampson, Tatsuo Fukagawa, Iain M. Cheeseman
Molecular Cell
Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase
Dan Liu, Mathijs Vleugel, Chelsea B. Backer, Tetsuya Hori, Tatsuo Fukagawa, Iain M. Cheeseman, Michael A. Lampson
The Journal of Cell Biology
Sensing centromere tension: Aurora B and the regulation of kinetochore function
Michael A. Lampson, Iain M. Cheeseman
Trends in Cell Biology
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome
Russell C. DeKelver, Vivian M. Choi, Erica A. Moehle, David E. Paschon, Dirk Hockemeyer, Sebastiaan H. Meijsing, Yasemin Sancak, Xiaoxia Cui, Eveline J. Steine, Jeffrey C. Miller, Phillip Y. Tam, Victor V. Bartsevich, Xiangdong Meng, Igor Rupniewski, Sunita M. Gopalan, Helena C. Sun, Kathleen Pitz, Jeremy M. Rock, Lei Zhang, Gregory D. Davis, Edward J. Rebar, Iain M. Cheeseman, Keith R. Yamamoto, David M. Sabatini, Rudolf Jaenisch, Philip D. Gregory, Fyodor D. Urnov
Genome Research
Aurora B kinase controls the targeting of the Astrin–SKAP complex to bioriented kinetochores
Jens C. Schmidt, Tomomi Kiyomitsu, Tetsuya Hori, Chelsea B. Backer, Tatsuo Fukagawa, Iain M. Cheeseman
The Journal of Cell Biology
Kinetochore assembly: if you build it, they will come
Karen E. Gascoigne, Iain M. Cheeseman
Current Opinion in Cell Biology
Tension at EMBO's Aneuploidy Workshop
Peter De Wulf, Iain M. Cheeseman
EMBO Reports
The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility
Julie P. I. Welburn, Ekaterina L. Grishchuk, Chelsea B. Backer, Elizabeth M. Wilson-Kubalek, John R. Yates, Iain M. Cheeseman
Developmental Cell
The CENP-S complex is essential for the stable assembly of outer kinetochore structure
Miho Amano, Aussie Suzuki, Tetsuya Hori, Chelsea B. Backer, Katsuya Okawa, Iain M. Cheeseman, Tatsuo Fukagawa
The Journal of Cell Biology
The Zn Finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis
Andrew M. Glazer, Alex W. Wilkinson, Chelsea B. Backer, Sylvain W. Lapan, Jennifer H. Gutzman, Iain M. Cheeseman, Peter W. Reddien
Developmental Biology
CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore
Tetsuya Hori, Miho Amano, Aussie Suzuki, Chelsea B. Backer, Julie P. I. Welburn, Yimin Dong, Bruce F. McEwen, Wei-Hao Shang, Emiko Suzuki, Katsuya Okawa, Iain M. Cheeseman, Tatsuo Fukagawa
Cell
Fibrils Connect Microtubule Tips with Kinetochores: A Mechanism to Couple Tubulin Dynamics to Chromosome Motion
J. Richard McIntosh, Ekaterina L. Grishchuk, Mary Morphew, Artem K. Efremov, Kirill Zhudenkov, Vladimir A. Volkov, Iain M. Cheeseman, Arshad Desai, David N. Mastronarde, Fazly I. Ataullakhanov
Cell
A new mechanism controlling kinetochore–microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex
Reto Gassmann, Anthony Essex, Jia-Sheng Hu, Paul S. Maddox, Fumio Motegi, Asako Sugimoto, Sean O’Rourke, Bruce Bowerman, Ian X. McLeod, John R. Yates, Karen Oegema, Iain M. Cheeseman, Arshad Desai
Genes & Development
Orientation and structure of the Ndc80 complex on the microtubule lattice
Elizabeth M. Wilson-Kubalek, Iain M. Cheeseman, Craig Yoshioka, Arshad Desai, Ronald A. Milligan
The Journal of Cell Biology
Toward a Molecular Structure of the Eukaryotic Kinetochore
Julie P. I. Welburn, Iain M. Cheeseman
Developmental Cell
Molecular architecture of the kinetochore–microtubule interface
Iain M. Cheeseman, Arshad Desai
Nature Reviews Molecular Cell Biology
KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates
Iain M. Cheeseman, Tetsuya Hori, Tatsuo Fukagawa, Arshad Desai
Molecular Biology of the Cell
The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore
Iain M. Cheeseman, Joshua S. Chappie, Elizabeth M. Wilson-Kubalek, Arshad Desai
Cell
The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
Masahiro Okada, Iain M. Cheeseman, Tetsuya Hori, Katsuya Okawa, Ian X. McLeod, John R. Yates, Arshad Desai, Tatsuo Fukagawa
Nature Cell Biology
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation
Susan L. Kline, Iain M. Cheeseman, Tetsuya Hori, Tatsuo Fukagawa, Arshad Desai
The Journal of Cell Biology
A Combined Approach for the Localization and Tandem Affinity Purification of Protein Complexes from Metazoans
Iain M. Cheeseman, Arshad Desai
Science s STKE
The CENP-F-like Proteins HCP-1 and HCP-2 Target CLASP to Kinetochores to Mediate Chromosome Segregation
Iain M. Cheeseman, Ian MacLeod, John R. Yates, Karen Oegema, Arshad Desai
Current Biology
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension
Iain M. Cheeseman, Sherry Niessen, Scott Anderson, Francie Hyndman, John R. Yates, Karen Oegema, Arshad Desai
Genes & Development
"Holo"er than thou: Chromosome segregation and kinetochore function in C. elegans
Paul S. Maddox, Karen Oegema, Arshad Desai, Iain M. Cheeseman
Chromosome Research
Cell division: AAAtacking the mitotic spindle
Iain M. Cheeseman, Arshad Desai
Current Biology
Cell division: feeling tense enough?
Cheeseman IM, Desai A
Nature
Architecture of the budding yeast kinetochore reveals a conserved molecular core
Stefan Westermann, Iain M. Cheeseman, Scott Anderson, John R. Yates, David G. Drubin, Georjana Barnes
The Journal of Cell Biology
Kinetochore Protein Interactions and their Regulation by the Aurora Kinase Ipl1p
Ching Shang, Tony R. Hazbun, Iain M. Cheeseman, Jennifer D. Aranda, Stanley Fields, David G. Drubin, Georjana Barnes
Molecular Biology of the Cell
Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p
Iain M. Cheeseman, Scott Anderson, Miri Jwa, Erin M. Green, Jung-seog Kang, John R. Yates, Clarence S.M. Chan, David G. Drubin, Georjana Barnes
Cell
Simple centromere, complex kinetochore
Iain M. Cheeseman, David G. Drubin, Georjana Barnes
The Journal of Cell Biology
Implication of a novel multiprotein Dam1p complex in outer kinetochore function
Iain M. Cheeseman, Christine Taylor Brew, Michael J. Wolyniak, Arshad Desai, Scott Anderson, Nemone Muster, John R. Yates, Tim C. Huffaker, David G. Drubin, Georjana Barnes
The Journal of Cell Biology
Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)–related protein Sli15 during chromosome segregation
Jung-seog Kang, Iain M. Cheeseman, George Kallstrom, Vel Murugan, Georjana Barnes, Clarence S.M. Chan
The Journal of Cell Biology
Mitotic Spindle Integrity and Kinetochore Function Linked by the Duo1p/Dam1p Complex
Iain M. Cheeseman, Maria Enquist-Newman, Thomas Müller‐Reichert, David G. Drubin, Georjana Barnes
The Journal of Cell Biology
Dad1p, Third Component of the Duo1p/Dam1p Complex Involved in Kinetochore Function and Mitotic Spindle Integrity
Maria Enquist-Newman, Iain M. Cheeseman, David Van Goor, David G. Drubin, Pamela B. Meluh, Georjana Barnes
Molecular Biology of the Cell
A cluster of five cell wall-associated receptor kinase genes, Wak1–5, are expressed in specific organs of Arabidopsis
Zheng‐Hui He, Iain M. Cheeseman, Deze He, Bruce D. Kohorn
Plant Molecular Biology
Timekeeping in the honey bee colony: integration of circadian rhythms and division of labor
Darrell Moore, J. Angel, Iain M. Cheeseman, Susan E. Fahrbach, Gene E. Robinson
Behavioral Ecology and Sociobiology
Saccharomyces cerevisiae Duo1p and Dam1p, Novel Proteins Involved in Mitotic Spindle Function
Christian Hofmann, Iain M. Cheeseman, Bruce L. Goode, Kent McDonald, Georjana Barnes, David G. Drubin
The Journal of Cell Biology
A highly specialized social grooming honey bee (Hymenoptera: Apidae)
Darrell Moore, J. Angel, Iain M. Cheeseman, Gene E. Robinson, Susan E. Fahrbach
Journal of Insect Behavior